Committed to Resolving All Your Chemistry Challenges

Our technical team boasts a diverse range of chemistry expertise, spanning asymmetric synthesis, organometallic chemistry, heterogeneous/homogeneous catalysis, heterocyclic synthesis, and enzymatic reactions. With the growing complexity of target molecules, adept material and time management skills are crucial to efficiently navigate lengthy sequences of multi-step synthesis within tight deadlines. Leveraging our experience, our chemists have adeptly synthesized compounds in multi-kilo quantities across more than 20 linear steps. We are poised to tackle your chemistry challenges and deliver effective solutions promptly.

Roughly 30% of agrochemicals and 20% of pharmaceutical drugs on the market contain fluorine, a characteristic known to induce significant modifications in their chemical, physical, and biological attributes. Direct chlorination and fluorination emerge as the most economically viable and effective approaches for synthesizing fluorine-containing compounds. However, executing these processes demands specialized equipment and expertise, notably when handling chlorine and HF. Our proficiency spans laboratory, pilot-scale, and large-scale manufacturing, enabling us to utilize these reagents safely and effectively. Rely on us as your premier partner for all direct chlorination and fluorination requirements.

Ensuring sustainability through green processes is a fundamental aspect of our corporate responsibility. We are committed to researching, developing, and implementing technologies and practices that minimize our environmental footprint. Embracing green initiatives drives us to explore innovative approaches and technologies for improved operations. Over the years, we have developed a comprehensive suite of green process solutions, including:

• Adoption of continuous flow processes where feasible.
• Integration of biocatalytic reactions as alternatives to conventional chemical methods.
• Preference for bio-based raw materials and solvents over petrochemical alternatives.
• Investment in and implementation of process automation technologies.
• Emphasis on recycling practices wherever feasible.

These initiatives underscore our dedication to sustainable practices and environmental stewardship.

Affinity is a global leader in providing the most comprehensive series of functionalized single molecular weight polyethylene glycol (PEG) products. We specialize in delivering cost-effective PEG linker products through efficient synthesis and scalable production methods, while prioritizing environmental sustainability by minimizing our carbon footprint through innovative technologies.

Our expertise in PEGylation of drugs and biomolecules offers significant advantages for enhancing drug efficacy and bioactivity. With our proprietary technology, we are poised to lead the field of PEGylation, driving advancements in pharmaceutical and biotechnological applications.

Affinity's Peptide and Oligonucleotide Group offers a comprehensive range of services and products tailored to meet diverse research and development needs:

Peptide Synthesis:

• Synthesis of peptides containing unnatural amino acids
• Preparation of isotopically labeled peptides
• Conjugation of peptides with oligonucleotides
• Conjugation of peptides with ligands
• Synthesis of fluorescence-labeled peptides
• Peptide library preparation and modification

Oligonucleotide Synthesis:

• Synthesis of antisense oligonucleotides
• Production of canonical small interfering RNAs (siRNAs)
• Preparation of bioconjugates involving oligonucleotides
• Synthesis of siRNA with 2’-sugar moiety-modified nucleosides (2’-F, 2’-OMe, 2’-MOE)
• Synthesis of siRNA with locked nucleic acids (LNA) and bridged nucleic acid (BNA)
• Synthesis of siRNA with internucleoside amide linkage